Related Experiment Video
Updated: Feb 11, 2026

Clinical Examination Protocol to Detect Atypical and Classical Scrapie in Sheep
Published on: January 19, 2014
Atypical Gianotti-Crosti syndrome
Aline Pantano Marcassi1, Christiane Affonso de Donato Piazza1, Maria Bandeira de Melo Paiva Seize1
1Outpatient Clinic of Pediatric Dermatology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
A rare case of Gianotti-Crosti syndrome presented atypically in a 22-month-old boy following Epstein-Barr virus infection. This highlights the varied clinical manifestations of this pediatric dermatosis.
Area of Science:
- Pediatric Dermatology
- Infectious Diseases
- Viral Infections
Background:
- Gianotti-Crosti syndrome (papular acrodermatitis of childhood) is a benign, self-limiting skin condition.
- Typically associated with viral exanthems, its presentation can vary.
- Epstein-Barr virus (EBV) is a common human herpesvirus with diverse clinical outcomes.
Observation:
- A 22-month-old male child presented with an unusual manifestation of Gianotti-Crosti syndrome.
- The child had a preceding infection with Epstein-Barr virus.
- The clinical presentation deviated from the typical Gianotti-Crosti syndrome features.
Findings:
- This case demonstrates an atypical clinical course of Gianotti-Crosti syndrome.
- Epstein-Barr virus infection was identified as the likely trigger.
- The unusual presentation underscores the variable clinical spectrum of this condition.
Implications:
- Highlights the importance of considering EBV as a cause of atypical Gianotti-Crosti syndrome.
- May prompt reevaluation of diagnostic criteria for Gianotti-Crosti syndrome.
- Contributes to understanding the diverse presentations of viral exanthems in children.
Related Concept Videos
Antipsychotic Drugs: Typical and Atypical Agents
Nephrotic Syndrome I : Introduction
Acute Coronary Syndrome I: Introduction
Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Restless Leg Syndrome and Night Terrors
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
Acute Coronary Syndrome V: Nursing Management

