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Related Concept Videos

Diffusion01:12

Diffusion

221.5K
Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
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Diffusion01:21

Diffusion

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Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
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Negative Regulator Molecules01:23

Negative Regulator Molecules

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Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
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Positive, Negative, and Zero Work00:58

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Work is done on an object when energy is transferred to the object. In other words, work is done when a force acts on a body that undergoes a displacement from one position to another. By definition, the work done by a force is the integral of the force with respect to the displacement along its path. Forces can vary as a function of position, and displacements can occur along various paths between two points. The magnitude of a force multiplied by the cosine of the angle that the force makes...
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Facilitated Diffusion01:16

Facilitated Diffusion

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The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
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Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

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Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
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Related Experiment Video

Updated: Feb 11, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Unclassifiable CD20-negative Testicular Diffuse Large B-cell Lymphoma.

Pablo Garrido-Abad1, Luis García-Martín1, Karen Villar-Zarra2

  • 1Urology Department, Hospital Universitario del Henares, Coslada, Madrid, Spain.

Urology
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Summary

CD20-negative diffuse large B-cell lymphoma (DLBCL) is rare and aggressive. This report details an unclassifiable CD20-negative DLBCL case presenting as a testicular mass, a highly unusual occurrence.

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Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • CD20-negative diffuse large B-cell lymphoma (DLBCL) is a rare subtype of non-Hodgkin lymphoma.
  • These lymphomas are characterized by an aggressive clinical course, chemoresistance, and poor prognosis.

Observation:

  • This report describes a unique case of CD20-negative DLBCL presenting as a testicular mass.
  • The tumor did not meet criteria for established CD20-negative DLBCL subtypes, classifying it as unclassifiable.

Findings:

  • The case highlights the potential for CD20-negative DLBCL to manifest in extranodal sites like the testis.
  • This presentation represents one of the first reported instances of unclassifiable CD20-negative DLBCL in the testis.

Implications:

  • This case expands the understanding of rare DLBCL presentations and locations.
  • Further research into CD20-negative DLBCL is warranted to improve diagnostic and therapeutic strategies for this aggressive malignancy.