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Related Experiment Video

Updated: Feb 11, 2026

Extracting Visual Evoked Potentials from EEG Data Recorded During fMRI-guided Transcranial Magnetic Stimulation

Extracting Visual Evoked Potentials from EEG Data Recorded During fMRI-guided Transcranial Magnetic Stimulation

Published on: May 12, 2014

Magnetic stimulation selectively affects pre-stimulus EEG microstates.

Pierpaolo Croce¹, Filippo Zappasodi¹, Sara Spadone¹

¹Department of Neuroscience Imaging and Clinical Science - and ITAB, Institute for Advanced Biomedical Technologies University "G. d'Annunzio", Chieti, Italy.

|May 4, 2018

Summary

This study reveals that pre-stimulus electroencephalography (EEG) microstates are task-specific. Brain stimulation over specific regions selectively alters these EEG markers, indicating their role in anticipating events.

Keywords:

EEG microstates Parietal cortex Pre-stimulus period TMS

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Area of Science:

Neuroscience
Cognitive Neuroscience
Electrophysiology

Background:

Anticipatory electroencephalography (EEG) markers, like alpha rhythm desynchronization (ERD), offer insights into cognitive processes preceding stimuli.
Previous research indicated local EEG markers are affected by transcranial magnetic stimulation (TMS) over specific brain networks.

Purpose of the Study:

To investigate if pre-stimulus EEG microstate topographies, a global measure of neural activity, exhibit task specificity.
To determine if TMS over specific brain regions causally influences these global EEG measures.

Main Methods:

Subjects underwent sham stimulation, revealing distinct pre-stimulus microstate topographies for perceptual versus memory tasks.
TMS was applied to the left intraparietal sulcus (IPS) and left angular gyrus (AG) during visuo-spatial attention and semantic memory tasks.

Main Results:

Distinct pre-stimulus EEG microstates were identified for perceptual and memory tasks under sham stimulation.
Stimulation of the left IPS, but not AG, altered microstates during visuo-spatial attention.
Stimulation of AG, but not IPS, altered microstates during semantic memory tasks.

Conclusions:

These findings provide causal evidence for the task and region specificity of pre-stimulus EEG microstates.
Pre-stimulus EEG microstates are proposed as a valuable index for assessing the period preceding predictable events.