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Breath Collection from Children for Disease Biomarker Discovery
Published on: February 14, 2019
[Characterization of children younger than five years with suspected allergic diseases]
Laura Mar Vásquez1, Manuela Olaya, Daniela Cleves
1Universidad ICESI, Facultad de Medicina, Cali, Valle del Cauca, Colombia. cdserranoreyes@gmail.com.
Insights
Allergic diseases are common in Colombian preschoolers, with respiratory symptoms being the main reason for visits. Dust mites were the most frequent allergens identified, and family history of allergy and bronchiolitis were significant risk factors.
Area of Science:
- Pediatric Allergy and Immunology
- Clinical Research in Childhood Diseases
Background:
- Allergic diseases frequently cause childhood consultations.
- Understanding the profile of pediatric patients in allergology is crucial for targeted interventions.
Purpose of the Study:
- To characterize Colombian preschool children attending an allergology department.
- To identify potential risk factors associated with allergic diseases in this population.
Main Methods:
- A descriptive, cross-sectional study was conducted over one year.
- Included 674 preschool children (<5 years) with medical history and allergy workup.
- Multivariate analysis assessed risk factors for allergic conditions.
Main Results:
- Respiratory symptoms (cough, wheezing, rhinitis) and eczema were primary consultation reasons.
- Dust mites and egg were the main identified allergens.
- Eczema linked to prematurity; recurrent cough/wheezing associated with family history of allergy and prior bronchiolitis.
Conclusions:
- Respiratory symptoms are the predominant reason for pediatric allergy consultations.
- Dust mites are the most common allergens in this cohort.
- Family history of allergy and a history of bronchiolitis are significant risk factors for recurrent respiratory symptoms.
Background:
Symptoms of allergic diseases are a common cause of consultation during childhood.
Objective:
To describe the profile of a population of Colombian preschool children seen in an allergology department and assess possible risk factors.
Methods:
Descriptive, cross-sectional study of patients younger than 5 years who were assessed for one year. A complete medical history was obtained and allergology workup was carried out with skin prick tests as appropriate for each case. Risk factors were assessed by means of multivariate analysis.
Results:
A total of 674 patients were included, out of which 382 (52.7%) were males. Median age was 34 months. The reasons for consultation were cough or recurrent wheezing (54.3%), rhinitis (48.7%), and eczema (32.2%). Skin prick tests were performed with aeroallergens in 299 patients (48%) and with food in 170 (27%), with positivity being found in 114 (38%) and 16 (9.4%), respectively. Main sensitizers were dust mites and egg. A direct association was found between eczema and prematurity (OR = 0.496; 95 % CI = 0.289-0.823)], between recurrent cough/wheezing and family history of allergy (OR = 1.837; 95 % CI = 1,306-2,586), and between recurrent cough/wheezing and history of bronchiolitis (OR = 2.646; 95 % CI = 1.812-3.886).
Conclusion:
Respiratory symptoms represented the main cause of consultation. Dust mites were the most commonly identified allergens. Family history of allergy and bronchiolitis.
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