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Updated: Feb 11, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Instrument for Assessing Knowledge of Oral Anticoagulant Therapy: Construction and Validation
Fernanda Souza E Silva Garcia, Débora Cristina Prévide Teixeira da Cunha, Rafaela de Oliveira Manzato
Background And Purpose:
A valid and reliable assessment tool is fundamental for evaluating the knowledge of individuals about using oral anticoagulant therapy (OAT). The purpose of this study was to develop a tool to assess knowledge about OAT and provide evidence to support its use in people living in developing countries.
Methods:
Construction and validation: development of items; assessment of face and content validity; pilot study; application of the instrument to a sample of 500 users of OAT to analyze dimensionality, convergent validation, and reliability.
Results:
Analysis of dimensionality suggested a unidimensional instrument. Direct correlation between knowledge of OAT and educational level was confirmed (r = .61, p < .001) (validity of construct). Reliability measured by KR-20 was 0.86.
Conclusions:
The new instrument was shown to be valid and reliable for assessing knowledge of OAT in the population studied.
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