Related Experiment Video

Updated: Feb 11, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
10:37

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

36.6K

Iodine-125 seed brachytherapy inhibits non-small cell lung cancer by suppressing epithelial-mesenchymal transition

Yana He1, Liang Li2, Jihua Liu3

  • 1Department of Medical Imaging, Second Hospital of Tianjin Medical University, Tianjin, China; Department of Medical Imaging, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Brachytherapy
|May 5, 2018
PubMed
Abstract

Insights

Iodine-125 (I-125) seed brachytherapy effectively treats non-small cell lung cancer (NSCLC) in mice. This treatment reduced tumors and improved survival by suppressing epithelial-mesenchymal transition (EMT).

Area of Science:

  • Oncology
  • Radiotherapy
  • Molecular Biology

Background:

  • Metastatic non-small cell lung cancer (NSCLC) presents a significant clinical challenge due to high mortality rates.
  • Iodine-125 (I-125) seed brachytherapy is an underutilized treatment modality for NSCLC.

Purpose of the Study:

  • To evaluate the efficacy of Iodine-125 (I-125) seed brachytherapy in a mouse model of non-small cell lung cancer (NSCLC).
  • To investigate the impact of I-125 seed brachytherapy on tumor progression, pathological changes, and survival rates.
  • To analyze the effect of I-125 seed brachytherapy on epithelial-mesenchymal transition (EMT) markers in NSCLC xenografts.

Main Methods:

  • A mouse xenograft model was established using human H23 NSCLC cells.
  • Mice underwent I-125 seed implantation for brachytherapy treatment.
  • Tumor volume, pathological impairments, and survival rates were assessed.
  • Expression levels of EMT markers (N-cadherin, E-cadherin, vimentin) were analyzed via RT-PCR and Western blot.

Main Results:

  • I-125 seed implantation significantly reduced tumor volume and pathological effects.
  • The treatment markedly improved the survival rate of the NSCLC model mice.
  • Expression patterns of N-cadherin, E-cadherin, and vimentin were reversed, indicating suppressed EMT.

Conclusions:

  • I-125 seed brachytherapy demonstrates significant inhibitory effects against non-small cell lung cancer (NSCLC).
  • The therapeutic mechanism involves the suppression of epithelial-mesenchymal transition (EMT).
  • These findings support the potential of I-125 seed brachytherapy as a viable treatment for NSCLC.
Keywords:
BrachytherapyEpithelial-mesenchymal transitionIodine-125Non–small cell lung cancer

More Related Videos

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

14.5K
Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

9.9K

Related Concept Videos

Phase Transitions02:31

Phase Transitions

Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
23.3K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.6K
Feedback Inhibition00:46

Feedback Inhibition

Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
57.3K
Properties of Transition Metals02:58

Properties of Transition Metals

Transition metals are defined as those elements that have partially filled d orbitals. As shown in Figure 1, the d-block elements in groups 3–12 are transition elements. The f-block elements, also called inner transition metals (the lanthanides and actinides), also meet this criterion because the d orbital is partially occupied before the f orbitals.
30.0K
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
8.9K
Seed Structure and Early Development of the Sporophyte02:33

Seed Structure and Early Development of the Sporophyte

Seed structures are composed of a protective seed coat surrounding a plant embryo, and a food store for the developing embryo. The embryo contains the precursor tissues for leaves, stem, and roots. The endosperm and cotyledons—seed leaves—act as the food reserves for the growing embryo.
31.3K