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Updated: Feb 11, 2026

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Inchworm bipedal nanowalker.

Y H Chiang1, S L Tsai, S R Tee

  • 1Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117542. phywangz@nus.edu.sg.

Nanoscale
|May 5, 2018
PubMed
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This study introduces a novel DNA-based nanowalker with identical legs, capable of unidirectional inchworm (IW) motion. It demonstrates controllable gait switching and direction reversal, advancing molecular robotics.

Area of Science:

  • Molecular Robotics
  • Nanotechnology
  • DNA Nanotechnology

Background:

  • Nanowalkers utilize either inchworm (IW) or hand-over-hand (HOH) gaits, with IW offering advantages in force, processivity, and integration.
  • Existing artificial IW nanowalkers require distinct 'head' and 'tail' components for directional movement.

Purpose of the Study:

  • To develop an inherently unidirectional IW nanowalker using identical bipedal legs.
  • To demonstrate controllable gait switching and direction reversal in artificial nanowalkers.

Main Methods:

  • Constructed a bipedal DNA nanowalker powered by a light-activated G-quadruplex engine.
  • Utilized a DNA duplex track with specific fluorescence patterns to verify IW gait and distinguish it from HOH gait.
  • Investigated gait switching and direction reversal by altering the separation of binding sites on the track.

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Main Results:

  • Successfully demonstrated an inherently unidirectional IW nanowalker with two identical legs.
  • Observed controllable switching between IW and HOH gaits.
  • Achieved direction reversal of the nanowalker by modifying the track's binding site periodicity.

Conclusions:

  • Presents a novel DNA nanowalker with inherent unidirectionality and controllable gait switching.
  • Offers an integrated mechanism for versatile nanowalker operation on various surfaces and potentials.
  • Advances the development of sophisticated molecular machines for nanotechnology applications.