Mandibular Catch-Up Growth in Pierre Robin Sequence: A Systematic Review

Area of Science:

• Craniofacial development
• Pediatric genetics
• Orthodontics

Background:

• Pierre Robin sequence (PRS) is characterized by mandibular hypoplasia.
• The notion of compensatory mandibular catch-up growth is frequently cited in PRS literature.
• Objective evidence supporting this concept requires critical evaluation.

Purpose of the Study:

• To systematically review the literature and assess the scientific support for mandibular catch-up growth in Pierre Robin sequence.
• To evaluate objective measurements of mandibular growth and position in nonoperatively managed PRS patients.

Main Methods:

• A PubMed-based systematic review of English-language articles was conducted.
• Studies focused on objective measurements of mandibular growth (length, ramus) and maxillomandibular discrepancy.
• Included articles involved nonoperative management of Pierre Robin sequence.

Main Results:

• 16 studies met inclusion criteria, with 8 longitudinal and 10 cross-sectional.
• Only a minority of longitudinal studies (2/8) reported significantly faster mandibular growth rates.
• Most studies (10/16) indicated a persistent posterior displacement of the mandible relative to the maxilla in PRS patients.

Conclusions:

• The concept of significant mandibular catch-up growth in Pierre Robin sequence lacks robust support from objective studies.
• Evidence for the complete resolution of maxillomandibular discrepancy in PRS is limited.
• Heterogeneity in study populations and methodologies complicates definitive conclusions.