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Lid-opening apraxia in Wilson's disease
1Department of Neurology, LAC/USC Medical Center.
Journal of Clinical Neuro-Ophthalmology
|March 1, 1988
Summary
Wilson's disease, a rare genetic disorder, can manifest with unusual neurological symptoms like intermittent inability to open eyes (lid-opening apraxia). This case highlights a previously unreported association between lid-opening apraxia and Wilson's disease.
Area of Science:
- Neurology
- Genetics
- Ophthalmology
Background:
- Wilson's disease is an inherited disorder of copper metabolism.
- Neurological symptoms are common in Wilson's disease, often involving movement disorders.
- Lid-opening apraxia is typically associated with diffuse extrapyramidal disease.
Observation:
- A student presented with severe, intermittent inability to open his eyes.
- This symptom prompted a neurologic evaluation.
- The underlying cause was diagnosed as Wilson's disease.
Findings:
- Lid-opening apraxia, a rare neurological sign, was observed in a patient with Wilson's disease.
- This represents a previously unreported clinical manifestation of Wilson's disease.
- The case expands the spectrum of neurological presentations for this condition.
Implications:
- Highlights the importance of considering Wilson's disease in the differential diagnosis of lid-opening apraxia.
- Suggests that copper metabolism disorders may present with a broader range of neurological and ophthalmological symptoms.
- Underscores the need for comprehensive neurological and metabolic workups in patients with unexplained movement or eye-opening difficulties.