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Cutaneous reactions to vitamin K
1Department of Dermatology, Mayo Clinic, Rochester, MN 55905.
Journal of the American Academy of Dermatology
|October 1, 1988
Summary
Vitamin K injections can cause delayed hypersensitivity reactions, leading to erythematous plaques. This rare side effect is often associated with liver disease treatment.
Area of Science:
- Dermatology
- Clinical Pharmacology
Background:
- Vitamin K is essential for blood coagulation.
- Vitamin K injections are used therapeutically, particularly in patients with liver disease.
Observation:
- Erythematous plaques developed in four patients following vitamin K injections.
- Literature review identified 36 similar cases.
Findings:
- The reaction is characterized as a delayed hypersensitivity.
- Most affected patients received vitamin K for liver disease.
- A late-onset sclerodermatous reaction is a rare manifestation.
Implications:
- Clinicians should be aware of potential hypersensitivity reactions to vitamin K.
- Differential diagnosis of skin reactions post-injection should consider vitamin K.
- Further research may elucidate mechanisms of delayed hypersensitivity to vitamin K.