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The correlation between obstructive sleep apnea and diabetic neuropathy: A meta-analysis
Xiandong Gu1, Xuming Luo1, Xiongbiao Wang1
1Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.
Primary Care Diabetes
|May 6, 2018
Summary
Obstructive sleep apnea (OSA) is linked to diabetic neuropathy, particularly in type 1 diabetes. This meta-analysis confirms a significant correlation, highlighting the importance of addressing sleep apnea in diabetic patients.
Area of Science:
- Neurology
- Endocrinology
- Sleep Medicine
Background:
- Diabetic neuropathy is a common complication of diabetes mellitus.
- Obstructive sleep apnea (OSA) is a prevalent sleep disorder.
- The relationship between OSA and diabetic neuropathy requires further investigation.
Purpose of the Study:
- To explore the correlation between obstructive sleep apnea (OSA) and diabetic neuropathy.
- To synthesize existing evidence through a meta-analysis.
Main Methods:
- A systematic literature search was conducted on PubMed, Embase, and Cochrane Library.
- Meta-analysis was performed using R 3.12, with odds ratio (OR) and 95% confidence interval (CI) to present effect size.
- Heterogeneity, publication bias, and sensitivity were assessed using standard statistical methods.
Main Results:
- Eleven studies with 1842 patients were included in the meta-analysis.
- A significant correlation was found between OSA and diabetic neuropathy (OR=1.84, 95% CI: 1.18-2.87).
- Subgroup analysis revealed a significant correlation between OSA and type 1 diabetic neuropathy (OR=1.97, 95% CI: 1.19-3.25).
Conclusions:
- Obstructive sleep apnea is significantly correlated with neuropathy in type 1 diabetes.
- No significant correlation was found between OSA and type 2 or type 1+2 diabetic neuropathy.
- These findings suggest a specific link between OSA and type 1 diabetic neuropathy.
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