The correlation between obstructive sleep apnea and diabetic neuropathy: A meta-analysis
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Updated: Feb 11, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Xiandong Gu1, Xuming Luo1, Xiongbiao Wang1
1Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.
Background:
The aim of this study was to explore the correlation between obstructive sleep apnea (OSA) and diabetic neuropathy.
Materials And Methods:
After working out searching strategy, literatures were screened from the electronic databases: PubMed, Embase, and the Cochrane library. R 3.12 was utilized to perform meta-analysis, and odds ratio (OR) and its 95% confidence interval (CI) were used to present effect size. Heterogeneity was assessed by χ2-based Q test and I2 statistics. Publication bias was estimated by Egger's test and sensitivity was evaluated by leave one out methods.
Results:
According to the criteria, a total of 11 studies with 1842 patients were enrolled in this study. With a significant heterogeneity (Q=31.83, I2=68.60%), the random effects model was utilized to assess the effect size of pooled data. A remarkable correlation was identified OSA and diabetic neuropathy (OR=1.84, 95% CI: 1.18-2.87) without publication bias (t=1.68, P=0.13). Meanwhile, the result of leave one out performed a well sensitivity. Moreover, the subgroup analyses presented that OSA was significantly correlated with type 1 diabetic neuropathy (OR=1.97, 95% CI: 1.19-3.25), but no remarkable correlation was identified between OSA and type 1 (OR=1.84, 95% CI: 0.86-3.93) or 1+2 (OR=1.30, 95% CI: 0.43-3.92) diabetic neuropathy.
Conclusion:
OSA was significantly correlated with neuropathy in type 1 diabetes, but not in type 2 and type 1+2 diabetes.
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