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Updated: Feb 11, 2026

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
Published on: November 17, 2015
Evaluation of the lubricating effect of magnesium stearate and glyceryl behenate solid lipid nanoparticles in a
Lizbeth Martínez-Acevedo1, María de la Luz Zambrano-Zaragoza2, Gustavo Vidal-Romero1
1Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Cuautitlán, Laboratorio de Investigación y Posgrado en Tecnología Farmacéutica, Av. 1o de mayo s/n, Cuautitlán Izcalli CP 54745, Estado de México, Mexico.
Abstract:
The aim of this study was to develop solid lipid nanoparticles (SLN) and introduce them into a direct compression process to evaluate their lubricant properties. The study consisted of preparing glyceryl behenate SLN (Compritol® 888 ATO) by hot dispersion, and magnesium stearate SLN by a novel nanoprecipitation/ion exchange method. The ejection force was measured for nanosystems and raw materials in a formulation typically used for direct compression. The smallest particle sizes obtained were 456 nm for Compritol® 888 ATO and 330 nm for magnesium stearate. Results show that the NPs used as lubricants in a direct compression model formulation provided efficient lubrication by maintaining the lubricating properties of the system, thereby decreasing the amount of lubricant used compared to the raw material. The lubricating effect showed an increase of 15-30% for magnesium stearate and Compritol® 888 ATO, compared to the raw material at concentrations above 2%.
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