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Hybrid structures based on gold nanoparticles and semiconductor quantum dots for biosensor applications
Margarita Kurochkina1, Elena Konshina1, Aleksandr Oseev2
1Centre of Information Optical Technologies, ITMO University, Saint Petersburg, Russia.
Nanotechnology, Science and Applications
|May 8, 2018
Summary
Semiconductor quantum dots (QD) and gold nanoparticle (Au NP) hybrid structures were fabricated for efficient protein biosensing. These optical biosensors demonstrate the ability to detect and quantify protein content using luminescence amplification.
Area of Science:
- Nanotechnology
- Biotechnology
- Materials Science
Background:
- Semiconductor quantum dots (QD) offer efficient transduction for biosensor applications.
- Self-assembled gold nanoparticles (Au NPs) enhance QD luminescence for improved biosensing.
Purpose of the Study:
- Fabricate hybrid structures using CdSe/ZnS QDs and Au NP arrays.
- Utilize these hybrid structures as effective optical biosensors for protein detection.
Main Methods:
- Hybrid structures fabricated via spin coating.
- Au NP arrays characterized by optical microscopy and absorption spectroscopy.
- Protein detection using confocal laser scanning microscopy.
Main Results:
- Increased processing temperature affected Au NP aggregate dimensions and plasmon resonance.
- CdSe/ZnS QD deposition on Au NP arrays enhanced absorption and red-shifted plasmon peaks.
- Exciton-plasmon enhancement of QD photoluminescence observed, correlating with BSA concentration.
Conclusions:
- Demonstrated the capability of Au NP/QD structures as optical biosensors.
- Established the potential for qualitative and quantitative protein determination in solutions.
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