Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Review of Medicinal Plants from the Anak Dalam Tribe of Jambi: An Evaluation of Their Potential for Diabetic Wound Healing Effects-Current Status and Future Perspectives.

Drug design, development and therapy·2026
Same author

Enhancing Antibacterial Activity of <i>Medinilla speciosa</i> Blume Fruits Against <i>Cutibacterium acnes</i> Through Phytosome Delivery: An In Vivo Study.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Nanocarrier-Mediated Delivery Systems of Phytochemicals to Enhance and Accelerate Diabetic Wound Healing Processes.

Drug design, development and therapy·2026
Same author

Adjunctive Cannabidiol for Drug-Resistant Epilepsy: A Systematic Review and Meta-Analysis of Randomized Trials Across Syndromes, Formulations, and Dose Ranges.

Therapeutics and clinical risk management·2026
Same author

Protection of Hygroscopic Pharmaceutical and Nutraceutical Active Ingredients via Film Coating Technologies: A Review.

Drug design, development and therapy·2026
Same author

Antihypertensive Plants Used by the Anak Dalam Tribe in Jambi, Indonesia: Ethnobotanical Insights and Pharmacological Potential as Alternatives to Conventional Medicine.

Drug design, development and therapy·2026
Same journal

Silver Nanoparticles Attenuate Histamine-Induced Pruritus via Modulation of the Nitric Oxide/iNOS Signaling Pathway in Mice.

Nanotechnology, science and applications·2026
Same journal

Three Noble Metal Nanoparticles Demonstrated Distinct Biological Interactions and Cell Death Pathways in Human Hepatocarcinoma Cell Lines.

Nanotechnology, science and applications·2026
Same journal

Parenteral Berberine vs Cisplatin- Loaded Lipid Nanoparticles - Development, Characterisation, Comparative Safety Profiling and Cytotoxicity in Cholangiocarcinoma Cell Models.

Nanotechnology, science and applications·2026
Same journal

A Cost-Effective Approach to Triphenylamine-Assisted Fabrication of Stable Cu<sub>2</sub>O Nanoparticles: Structural Analysis and Multifunctional Antibacterial, Optical, and Electronic Performance.

Nanotechnology, science and applications·2026
Same journal

Surface-Modified Superparamagnetic Iron Oxide Nanoparticles (SPIONs) in a New Perspective for Prostate Cancer Therapy.

Nanotechnology, science and applications·2026
Same journal

Labeling of Amine-Modified Material Surfaces with PFB-Fluorescein.

Nanotechnology, science and applications·2026
See all related articles

Related Experiment Video

Updated: Apr 23, 2026

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
07:53

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

10.2K

Sacha Inchi Oil-Based Nanostructured Lipid Carriers for Curcumin Delivery: Development and Physicochemical

Ikra Nurohman1,2, Anis Yohana Chaerunisaa2, Gofarana Wilar3

  • 1Doctoral Program of Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, Indonesia.

Nanotechnology, Science and Applications
|April 22, 2026
PubMed
Summary
This summary is machine-generated.

Sacha inchi oil enhances curcumin-loaded nanostructured lipid carriers (NLCs), improving stability and drug delivery. These novel NLCs show potential for managing degenerative diseases through sustained curcumin release.

Keywords:
curcumindrug deliverylipid-based nanoparticlenanostructured lipid carrierssacha inchi oil

More Related Videos

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.3K
Formulation and Characterization of Bioactive Agent Containing Nanodisks
07:58

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

1.8K

Related Experiment Videos

Last Updated: Apr 23, 2026

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
07:53

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

10.2K
Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.3K
Formulation and Characterization of Bioactive Agent Containing Nanodisks
07:58

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

1.8K

Area of Science:

  • Nanotechnology
  • Drug Delivery Systems
  • Lipid-Based Formulations

Background:

  • Curcumin's antioxidant properties are hindered by poor solubility and stability.
  • Nanostructured lipid carriers (NLCs) offer a solution for formulating lipophilic drugs.
  • Sacha inchi oil is explored as a novel liquid lipid for enhanced NLC performance.

Purpose of the Study:

  • To develop and characterize curcumin-loaded NLCs using sacha inchi oil as a liquid lipid.
  • To evaluate the physicochemical properties and in vitro release of the developed NLCs.
  • To assess the potential of sacha inchi oil-based NLCs as a stable curcumin delivery system.

Main Methods:

  • Curcumin-loaded NLCs were prepared via hot homogenization and probe sonication.
  • Formulations utilized various solid lipids, sacha inchi oil, and surfactants.
  • Characterization included particle size, PDI, ZP, EE, FTIR, DSC, XRD, morphology, and in vitro release studies.

Main Results:

  • The optimal formulation (CaTS2) exhibited a particle size of 95.50 nm, PDI of 0.119, and ZP of -22.30 mV.
  • High entrapment efficiency (97.24%) and spherical morphology were achieved.
  • In vitro release showed a biphasic pattern with sustained release, following the Korsmeyer-Peppas model.

Conclusions:

  • Sacha inchi oil-based NLCs were successfully developed for curcumin delivery.
  • The NLCs demonstrated favorable physicochemical properties and stability.
  • These findings support the potential of NLCs as an effective system for curcumin delivery.