Mouse models of multiple myeloma: technologic platforms and perspectives.

Area of Science:

• Oncology
• Hematology
• Pre-clinical Research

Background:

• Murine models are essential for studying multiple myeloma (MM) biology and testing new therapies.
• Recent advancements have led to diverse pre-clinical models that mimic MM's complexity.
• Choosing the appropriate model is critical for research success.

Purpose of the Study:

• To review current pre-clinical murine, transgenic, and humanized models for multiple myeloma.
• To analyze the advantages and disadvantages of each model type.
• To guide researchers in selecting the most suitable model for their specific research objectives.

Main Methods:

• Review of published literature on pre-clinical multiple myeloma models.
• Categorization of models including spontaneous, transgenic, xenograft, and humanized systems.
• Comparative analysis of model systems based on biological fidelity and research applicability.

Main Results:

• Various models exist, including spontaneous/transgenic murine MM, xenografts of human MM cell lines, and humanized models engrafting primary MM cells.
• Each model type offers unique advantages for studying specific aspects of MM.
• Key limitations and strengths are identified for each model, influencing their suitability for different research aims.

Conclusions:

• A range of sophisticated pre-clinical models are available for multiple myeloma research.
• Understanding the specific advantages and limitations of each model is vital for effective therapeutic development and disease research.
• This review provides a framework for selecting optimal models to advance multiple myeloma studies.