Intramolecular hydride transfer onto arynes: redox-neutral and transition metal-free C(sp3)-H functionalization of
Fahima I M Idiris1, Cécile E Majesté1, Gregory B Craven1
1School of Biological and Chemical Sciences , Queen Mary University of London , Mile End Road , London , E1 4NS , UK .
Abstract:
Transition metal-free intramolecular hydride transfer onto arynes is reported for the first time. This unique transformation is utilized in redox-neutral intermolecular α-functionalization reactions of different tertiary amines, generating C(sp3)-C(sp3/sp2/sp) bonds in a single synthetic operation. Deuterium labeling studies support initial cleavage of the α-C-H bond via intramolecular 1,5-hydride transfer onto the aryne, which leads to activation of a range of integrated pronucleophiles and ultimately affords a new approach to cross-dehydrogenative coupling reactions which utilize aryne intermediates.
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