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Updated: Feb 11, 2026

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research
Published on: October 20, 2023
Successful Use of Sternal-Sparing Minimally Invasive Surgery for Proximal Ascending Aortic Pathology
Joseph Lamelas1, Peter C Chen2, Gabriel Loor2
1Department of Cardiothoracic Surgery, Baylor College of Medicine, CHI St. Luke's Health-Baylor St. Luke's Medical Center, Houston, Texas; Division of Cardiovascular Surgery, Texas Heart Institute, Houston, Texas.
Background:
A sternal-sparing approach to surgery of the proximal aorta could decrease postoperative morbidity.
Methods:
To determine the potential benefits of using a minimally invasive right thoracotomy approach for the treatment of ascending aortic pathology, we retrospectively reviewed our experience in patients who required circulatory arrest for the treatment of ascending aortic pathology (with or without aortic valve involvement) between January 2009 and November 2014 (N = 177). We compared baseline characteristics, intraoperative characteristics, and postoperative clinical outcomes between those who underwent a sternotomy (n = 103) and those who underwent a minimally invasive right thoracotomy approach (n = 74). All surgical procedures were performed by a single surgeon. Propensity score matching was performed to account for baseline differences between groups.
Results:
More patients in the minimally invasive group had bicuspid aortic valve, degenerative aortic valve, or aortic insufficiency than in the sternotomy group, but other baseline characteristics were similar between groups. No strokes occurred. In the unmatched cohort, 30-day mortality was 2.7% for the minimally invasive group compared with 1.9% for the sternotomy group (p = 1.00). In the propensity score-matched cohort, 30-day mortality was 3.2% for both groups; circulatory arrest times were longer in the minimally invasive group than in the sternotomy group (p < 0.0001), but the minimally invasive group had fewer red blood cell transfusions, shorter ventilation times, and shorter intensive care unit and hospital length of stay.
Conclusions:
A sternal-sparing approach to surgery of the proximal aorta is safe when performed by an experienced surgeon and conserves hospital resources.
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Types of Errors: Detection and Minimization
Absolute error in a measurement is the numerical difference from the true or central value. Relative error is the ratio between absolute error and the true or central value, expressed as a percentage.
Errors can be classified by source, magnitude, and sign. There are three types of errors: systematic, random, and gross.
Systematic or...

