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Cutaneous toxicity as a predictive biomarker for clinical outcome in patients receiving anticancer therapy

Alexandra K Rzepecki1, Haiying Cheng2, Beth N McLellan3

  • 1Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan.

Journal of the American Academy of Dermatology
|May 8, 2018
PubMed

Insights

Skin toxicities from cancer treatments like targeted therapies and chemotherapy may indicate treatment effectiveness. Further research is needed, but recognizing these side effects can guide cancer treatment decisions and improve patient outcomes.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Cutaneous toxicity from anticancer therapies is increasingly recognized.
  • The link between skin side effects and treatment efficacy is a growing area of research.

Purpose of the Study:

  • To review the association between skin toxicities and survival benefit across major anticancer agent classes.
  • To highlight the potential of cutaneous toxicities as biomarkers for treatment efficacy.

Main Methods:

  • Literature review of studies on molecularly targeted kinase inhibitors, immune checkpoint inhibitors, and cytotoxic chemotherapeutics.
  • Analysis of data correlating cutaneous toxicity with treatment outcomes and survival.

Main Results:

  • Preliminary data suggest a promising association between specific cutaneous toxicities and improved survival.
  • The relationship varies across different classes of anticancer agents.

Conclusions:

  • Cutaneous toxicities may serve as surrogate biomarkers for anticancer therapy efficacy.
  • Larger prospective studies are required to validate these findings.
  • Dermatologist-oncologist collaboration is crucial for managing these toxicities and optimizing patient care.
Keywords:
biomarkercancer outcomecutaneous adverse eventcutaneous toxicityoncodermatologyprognostic markersurvival

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