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Published on: February 14, 2022
Cryoelectrolysis for Treatment of Atrial Fibrillation: A First Order Feasibility Study
M Hjouj1, H Krishnan2, B Rubinsky2
1The Medical Imaging Department, Faculty of Health Professions Al Quds University, Jerusalem, Palestinian Authority. mhjouj@staff.alquds.edu and mhjouj@hotmail.com.
Abstract:
BACKGROUND: Catheter based treatment of atrial fibrillation (AFib) involves ablation of groups of cells near the pulmonary vein.
Objective:
The goal of this study was to evaluate the technological feasability of a new technology for catheter-based ablation for treatment of AFib that combines freezing with electrolysis.
Materials And Methods:
The study was performed on a pH dye stained gel phantom of the pulmonary vein. Freezing was induced with a cryosurgical probe inserted in the vein and electrolysis was delivered through the probe with a DC power supply.
Results:
Visual recording of colorimetric changes in pH demonstrate that electrolytic products can propagate through the frozen tissue phantom. For example, a voltage of 9 V and a current of 40 mA delivered through a -15 degree C cryosurgical probe produced an electrolysis impacted rim of over 7 mm width in 2 min.
Conclusion:
This early stage experimental work suggests that cryoelectrolysis may have potential for treatment of AFib.
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