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Updated: Feb 11, 2026

Vitrification of In Vitro Matured Oocytes Collected from Adult and Prepubertal Ovaries in Sheep
Published on: July 10, 2021
Vitrfication and Slow Freezing for Cryopreservation of Germinal Vesicle-Stage Human Oocytes: A Bayesian Meta-Analysis
1Center for Reproductive Medicine, Eroom Women's Clinic, Busan, Republic of Korea. bridge53@naver.com.
Background:
T he most commonly used methods for the cryopreservation of oocytes and embryos are vitrification and slow freezing.
Objective:
The aim of this study was to to investigate whether there are differences in survival, in vitro maturation (IVM), and fertilization rates between cryopreserved immature oocytes, especially germinal vesicle (GV)-stage human oocytes, following vitrification and slow freezing.
Materials And Methods:
A literature search was performed using the MEDLINE, Cochrane Central Register of Controlled Trials, and Embase databases. A total of three studies were included in the Bayesian meta-analysis.
Results:
There was no difference in survival rates between vitrification and slow freezing. Additionally, there was no difference in IVM rates and fertilization rates between vitrification and slow freezing.
Conclusion:
The superiority of vitrification over slow freezing for cryopreservation of GV-stage human oocytes remains unclear. Additional studies on cytoarchitecture and modification of the cryopreservation protocol are essential to achieve strong conclusions.
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