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Updated: Feb 11, 2026

Transplantation of Zebrafish Pediatric Brain Tumors into Immune-competent Hosts for Long-term Study of Tumor Cell Behavior and Drug Response
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Pediatric Intestinal Transplantation

Neslihan Celik1, George V Mazariegos1, Kyle Soltys1

  • 1Department of Surgery, Division of Pediatric Transplantation, Hillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of UPMC, 4401 Penn Avenue, Pittsburgh, PA 15224, USA.

Gastroenterology Clinics of North America
|May 9, 2018
PubMed

Insights

Pediatric intestinal transplantation is now a viable therapy for children with intestinal failure. While outcomes improve, long-term graft function faces challenges from chronic rejection and immunosuppression side effects.

Area of Science:

  • Gastroenterology and Hepatology
  • Transplantation Surgery
  • Pediatric Surgery

Background:

  • Pediatric intestinal transplantation is an established therapy for irreversible intestinal failure.
  • Advancements in managing intestinal failure and parenteral nutrition complications have improved outcomes.
  • Reduced incidence of parenteral nutrition-associated liver disease and enhanced intestinal adaptation are noted.

Purpose of the Study:

  • To review the evolving indications for pediatric intestinal transplantation.
  • To discuss improvements in long-term outcomes.
  • To identify persistent challenges in long-term graft function.

Main Methods:

  • Literature review of pediatric intestinal transplantation.
  • Analysis of trends in indications and outcomes.
  • Discussion of current challenges and future directions.

Main Results:

  • Pediatric intestinal transplantation is a recognized treatment for specific pediatric conditions.
  • Indications are shifting due to better management of intestinal failure and its complications.
  • Long-term graft survival has improved, but chronic rejection and immunosuppression issues persist.

Conclusions:

  • Pediatric intestinal transplantation offers a life-saving option for children with intestinal failure.
  • Ongoing research is needed to overcome challenges in long-term graft function and immunosuppression.
  • Further improvements in managing chronic rejection are crucial for sustained success.

Keywords:
ImmunosuppressionIntestinal failurePediatric intestinal transplantationShort gut syndrome

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