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Updated: Feb 11, 2026
08:34
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
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Protons vs Photons for Brain and Skull Base Tumors
Safia K Ahmed1, Paul D Brown1, Robert L Foote1
1Department of Radiation Oncology, Mayo Clinic, Rochester, MN.
Seminars in Radiation Oncology
|May 9, 2018
Summary
Proton therapy offers superior dose conformity for brain and skull base tumors compared to photon therapy. This technique may improve tumor control and reduce radiation side effects in adults.
Area of Science:
- Radiation Oncology
- Medical Physics
- Neurosurgery
Background:
- Photon therapy is the standard for brain and skull base tumors.
- Proton therapy offers unique physical characteristics for radiation delivery.
- Understanding the comparative efficacy and safety of proton vs. photon therapy is crucial.
Purpose of the Study:
- To review the existing literature on proton therapy versus photon therapy for adult brain and skull base tumors.
- To evaluate the role of proton therapy in dose escalation and toxicity mitigation.
Main Methods:
- Systematic literature review of comparative studies.
- Analysis of studies focusing on dose distribution, tumor control, and adverse effects.
- Synthesis of evidence for proton and photon therapy in adult neuro-oncology.
Main Results:
- Proton therapy demonstrates steeper dose gradients and superior dose conformality.
- These characteristics are advantageous for dose escalation in skull base tumors.
- Potential for reduced radiation-related adverse effects in brain tumor treatment.
Conclusions:
- Proton therapy presents a promising alternative for specific adult brain and skull base tumors.
- Its physical advantages may enhance tumor control and patient safety.
- Further research is warranted to solidify its role in neuro-oncology.
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