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Updated: Feb 11, 2026
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Roux-en-Y Gastric Bypass Operation in Rats
Published on: June 11, 2012
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Severe anemia after Roux-en-Y gastric bypass: a cause for concern
Emily McCracken1, G Craig Wood2, Wesley Prichard3
1Department of Surgery, Geisinger Medical Center, Danville, Pennsylvania.
Summary
Metabolic surgery patients face high rates of anemia, with 11% experiencing severe anemia 5 years post-Roux-en-Y gastric bypass (RYGB). Risk factors include age, preoperative anemia, low ferritin, and rapid weight loss.
Area of Science:
- Bariatric Surgery
- Nutritional Complications
- Gastroenterology
Background:
- Metabolic surgery is increasingly popular.
- Long-term nutritional complications are a growing concern.
Purpose of the Study:
- To determine the long-term incidence of clinically significant anemia after Roux-en-Y gastric bypass (RYGB).
- To identify risk factors for developing anemia post-RYGB.
Main Methods:
- Retrospective study of 2116 RYGB patients and 1126 matched controls.
- Longitudinal follow-up using Kaplan-Meier analysis for anemia incidence.
- Cox regression to identify predictors of severe anemia.
Main Results:
- Anemia rates at 5 years post-RYGB: 68% mild, 33% moderate, 11% severe.
- RYGB patients had higher anemia rates than controls (HRs 1.36-1.87).
- Risk factors for severe anemia: female/male >40, preoperative anemia/low ferritin, rapid weight loss.
Conclusions:
- Clinically significant anemia is alarmingly common long-term after RYGB.
- Further research is needed to address this complication.
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