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[Nicorandil improves cognitive dysfunction in mice with streptozotocin-induced diabetes]

Wen-Hui Yan1, Chun-Xi Zhang, Tong Xing

  • 1Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.

Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University
|May 9, 2018
PubMed
Abstract

Insights

Nicorandil, a potassium channel opener, mitigates cognitive decline in diabetic mice by enhancing brain GIP and GLP-1 levels and reducing oxidative stress. This study highlights its potential therapeutic role in diabetic cognitive dysfunction.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Pharmacology

Background:

  • Type 1 diabetes mellitus (T1DM) induced by streptozotocin (STZ) in mice leads to cognitive dysfunction.
  • Diabetic conditions are associated with impaired hippocampal function and oxidative stress.

Purpose of the Study:

  • To investigate the neuroprotective effects of nicorandil in a mouse model of STZ-induced diabetes.
  • To evaluate nicorandil's impact on cognitive behavior, hippocampal neurochemistry, and oxidative stress markers.

Main Methods:

  • Established C57BL/6J mouse models of T1DM using STZ.
  • Administered nicorandil or saline daily for 4 weeks, with a control group.
  • Assessed cognitive function using the Morris water maze and analyzed hippocampal GIP, GLP-1, brain SOD, and MDA levels.

Main Results:

  • STZ-induced diabetes mice exhibited impaired cognitive function, increased blood glucose, and hippocampal/pancreatic ultrastructural damage.
  • Nicorandil treatment did not alter blood glucose but significantly improved cognitive performance and hippocampal neuron/synapse ultrastructure.
  • Nicorandil increased hippocampal GIP and GLP-1, boosted SOD activity, and decreased MDA levels in the brain.

Conclusions:

  • Nicorandil effectively ameliorates cognitive dysfunction in STZ-induced diabetic mice.
  • The protective effects are attributed to increased hippocampal GIP and GLP-1 and enhanced antioxidant capacity.
  • Nicorandil shows promise for treating cognitive impairments associated with diabetes.

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