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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
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LncRNA-Regulated Autophagy and its Potential Role in Drug-Induced Liver Injury
Juan Zhou1, Yi Li2, XinYu Liu1
1Liver Diseases Center, Department of Infectious Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Annals of Hepatology
|May 9, 2018
Summary
Long noncoding RNAs (lncRNAs) regulate autophagy, a cellular process vital for clearing damaged components. This review explores how lncRNAs impact autophagy in drug-induced liver injury (DILI), offering insights into disease mechanisms.
Area of Science:
- Cellular Biology
- Molecular Biology
- Hepatology
Background:
- Autophagy is a critical cellular process involved in maintaining homeostasis and responding to stress.
- Dysregulation of autophagy is implicated in various pathological conditions, including drug-induced liver injury (DILI).
- Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular processes, including autophagy.
Purpose of the Study:
- To review recent literature on the role of autophagy in DILI.
- To elucidate the regulatory mechanisms of autophagy by lncRNAs in the context of DILI.
- To provide insights into potential therapeutic targets for DILI.
Main Methods:
- Comprehensive literature search using keywords such as DILI, autophagy, autophagy-related genes (ATGs), and lncRNA.
- Systematic review and analysis of relevant published studies from major scientific databases.
- Synthesis of findings to describe lncRNA-mediated regulation of autophagy in DILI.
Main Results:
- DILI and its progression to acute liver failure are linked to endoplasmic reticulum stress and subsequent autophagy induction.
- Autophagy plays a protective role in hepatocytes during DILI.
- lncRNAs modulate autophagy by regulating the expression of autophagy-related genes (ATGs).
Conclusions:
- lncRNAs are significant regulators of autophagy in DILI.
- Understanding lncRNA-autophagy pathways offers new perspectives on DILI pathogenesis.
- Further research into lncRNA-miRNA-associated pathways could reveal novel therapeutic strategies for DILI.
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