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Updated: Feb 10, 2026

Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice
Published on: October 27, 2020
High-speed volumetric imaging of neuronal activity in freely moving rodents
Oliver Skocek1, Tobias Nöbauer1, Lukas Weilguny2
1Laboratory of Neurotechnology and Biophysics, The Rockefeller University, New York, NY, USA.
Abstract:
Thus far, optical recording of neuronal activity in freely behaving animals has been limited to a thin axial range. We present a head-mounted miniaturized light-field microscope (MiniLFM) capable of capturing neuronal network activity within a volume of 700 × 600 × 360 µm3 at 16 Hz in the hippocampus of freely moving mice. We demonstrate that neurons separated by as little as ~15 µm and at depths up to 360 µm can be discriminated.
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