Lower cervical spondylosis and myelopathy in adults with Down's syndrome

Abnormalities in the upper cervical spine resulting in cervical myelopathy in patients with Down's syndrome have been well-documented. However, two adult Down's syndrome patients recently presented with cervical myelopathy secondary to abnormalities of the lower cervical spine. Because of this, 105 Down's syndrome patients with normal upper cervical spines were evaluated clinically and radiographically. They were found to have an increased prevalence of lower cervical spondylosis that significantly correlated with physical findings consistent with cervical myelopathy. Therefore, physicians dealing with Down's patients should closely monitor neurological function and obtain flexion/extension laterals of the cervical spine to evaluate C1-C2 instability and degenerative changes in the lower cervical spine if a change in neurologic status is noted.