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Updated: Feb 10, 2026

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages
Published on: May 30, 2019
Phenotypic Screening of Small Molecules with Antimalarial Activity for Three Different Parasitic Life Stages
Nobutaka Kato1, Sandra March2,3,4,5, Sangeeta N Bhatia2,3,4,5
1Broad Institute of MIT and Harvard, Cambridge, MA, USA. nkato@broadinstitute.org.
Abstract:
Malaria remains one of the deadliest infectious diseases globally. Available therapeutic agents are already limited in their efficacy, and drug resistance threatens to diminish further our ability to prevent and treat the disease. Despite a renewed effort to identify compounds with antimalarial activity, the drug discovery and development pipeline lacks target diversity and availability of compounds that target liver- and gametocyte-stage parasites. Phenotypic screens are a powerful and valuable tool for identifying new chemical compounds with antimalarial activity. This chapter highlights recent phenotypic screening methodologies for all three parasitic life stages.
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