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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

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Accessing the Open PHACTS Discovery Platform with Workflow Tools.

Daniela Digles¹, Andrei Caracoti², Edgar Jacoby³

¹Department of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria. daniela.digles@univie.ac.at.

Methods in Molecular Biology (Clifton, N.J.)

|May 9, 2018

Summary

This summary is machine-generated.

The Open PHACTS Discovery Platform aids phenotypic screening by integrating public databases. Workflows for KNIME and Pipeline Pilot enable annotation of screening hits with compound and target information.

Keywords:

KNIME Open PHACTS Phenotypic screening Pipeline Pilot Workflow tool

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Area of Science:

Drug discovery
Cheminformatics
Bioinformatics

Background:

Phenotypic screening campaigns generate large datasets requiring robust annotation.
Publicly available databases offer valuable information for interpreting screening results.
Integrating diverse data sources is crucial for efficient drug discovery.

Purpose of the Study:

To demonstrate the utility of the Open PHACTS Discovery Platform for annotating phenotypic screening data.
To provide practical protocols for creating custom workflows using KNIME and Pipeline Pilot.
To facilitate the annotation of screening hits with compound classification and target information.

Main Methods:

Utilized the Open PHACTS Discovery Platform.
Developed custom workflows using KNIME and Pipeline Pilot.
Implemented protocols for annotating compounds with classification and target data.

Main Results:

Successfully integrated multiple public databases via workflow tools.
Established protocols for annotating phenotypic screening hits.
Enabled annotation with compound classification and protein target information.

Conclusions:

Workflow tools offer a customizable approach to accessing and utilizing the Open PHACTS Discovery Platform.
The described protocols streamline the annotation process for phenotypic screening hits.
Enhanced data annotation supports more effective drug discovery efforts.