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Related Experiment Video

Updated: Feb 10, 2026

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

Microfluidics-Enabled Multimaterial Maskless Stereolithographic Bioprinting.

Amir K Miri^1,2, Daniel Nieto^1,2,3, Luis Iglesias^1,2

¹Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.

Advanced Materials (Deerfield Beach, Fla.)

|May 9, 2018

Summary

This study introduces a stereolithography bioprinting platform for creating complex, multimaterial hydrogel constructs. The system enables high-resolution, layer-by-layer fabrication for tissue engineering and regenerative medicine applications.

Keywords:

bioprinting digital light prototyping digital micromirror devices microfluidics multimaterials

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Last Updated: Feb 10, 2026

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

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Published on: August 11, 2017

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Published on: March 9, 2021

Stereolithographic 3D Printing with Renewable Acrylates

Stereolithographic 3D Printing with Renewable Acrylates

Published on: September 12, 2018

Area of Science:

Biotechnology
Materials Science
Regenerative Medicine

Background:

Conventional stereolithography struggles with multimaterial fabrication.
High-resolution patterning of heterogeneous hydrogels is crucial for advanced tissue engineering.

Purpose of the Study:

To develop a stereolithography-based bioprinting platform for multimaterial hydrogel construct fabrication.
To demonstrate high spatial resolution and biocompatibility for tissue engineering applications.

Main Methods:

Utilized a digital micromirror device for dynamic patterning.
Integrated a novel microfluidic device with pneumatic valves for rapid bioink switching.
Fabricated constructs using poly(ethylene glycol) diacrylate (PEGDA) and gelatin methacryloyl (GelMA).

Main Results:

Achieved layer-by-layer multimaterial bioprinting with high spatial resolution.
Demonstrated biocompatibility through fabrication of cellularized constructs.
Assessed neovascularization potential of patterned hydrogels in a rat model.

Conclusions:

The developed platform enables on-demand, high-fidelity multimaterial bioprinting.
This system offers advantages over conventional methods for tissue engineering, regenerative medicine, and biosensing.