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Related Experiment Videos

Adaptive deep brain stimulation for Parkinson's disease using motor cortex sensing.

Nicole C Swann1,2, Coralie de Hemptinne1, Margaret C Thompson3

  • 1Departments of Neurological Surgery, University of California, San Franciso, CA, United States of America.

Journal of Neural Engineering
|May 10, 2018
PubMed
Summary

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Adaptive deep brain stimulation (DBS) for Parkinson's disease is feasible using a fully implanted device. This new approach demonstrated significant energy savings while maintaining therapeutic efficacy in patients.

Area of Science:

  • Neuroscience
  • Biomedical Engineering

Background:

  • Current deep brain stimulation (DBS) for Parkinson's disease is continuous and requires manual adjustments.
  • Continuous DBS can lead to energy inefficiency and adverse effects like dyskinesia.
  • Adaptive DBS offers a potential solution by adjusting stimulation in real-time based on neural signals.

Purpose of the Study:

  • To demonstrate the feasibility of adaptive deep brain stimulation (DBS) using a fully implanted neural prosthesis.
  • To investigate real-time adjustment of DBS based on neural signals in Parkinson's disease patients.

Main Methods:

  • Developed and tested a fully implanted neural prosthesis for adaptive DBS in two Parkinson's disease patients.
  • Utilized cortical narrowband gamma oscillations (60-90 Hz) to control stimulation amplitude in response to dyskinesia.

Related Experiment Videos

  • Decreased stimulation voltage when gamma activity was high (indicating dyskinesia) and increased it when low.

    • Main Results:

    • Successfully demonstrated the feasibility of adaptive DBS in two Parkinson's disease patients.
    • Achieved substantial energy savings of 38%-45% in short-term in-clinic testing.
    • Maintained therapeutic efficacy of the deep brain stimulation.

    Conclusions:

    • This study represents the first demonstration of adaptive DBS for Parkinson's disease using a fully implanted device with neural sensing.
    • The adaptive DBS approach showed significant energy savings and maintained therapeutic benefits.
    • This novel strategy offers a distinct method for feedback control in Parkinson's disease treatment.