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Long-Term Survival of Young Patients Surviving ICU Admission With Severe Sepsis

Heba Abu-Kaf1,2, Yuval Mizrakli2, Victor Novack

  • 1Department of Internal Medicine 'D', Division of Internal Medicine, Soroka University Medical Center, Beer Sheva, Israel.

Critical Care Medicine
|May 10, 2018
PubMed

Insights

Young patients with severe sepsis face higher long-term mortality risks, especially within the first two years post-discharge. Underlying health conditions may contribute to this increased sepsis mortality.

Area of Science:

  • Critical Care Medicine
  • Epidemiology
  • Public Health

Background:

  • Sepsis is a life-threatening condition with significant mortality.
  • Assessing long-term survival in young severe sepsis survivors is crucial for understanding disease impact.

Purpose of the Study:

  • To evaluate the long-term survival rates of young patients diagnosed with severe sepsis.
  • To identify mortality risks associated with severe sepsis in a younger demographic.

Main Methods:

  • Retrospective cohort study involving 409 young sepsis survivors and 818 matched controls.
  • Data collected from seven tertiary hospitals between 2003 and 2011.
  • Age and sex matching used for comparison between sepsis and non-sepsis patient groups.

Main Results:

  • Severe sepsis survivors had significantly lower survival rates compared to controls.
  • 3-year mortality rates were 10.8% for sepsis survivors versus 1.8% for controls (p < 0.001).
  • Sepsis was an independent risk factor for mortality within 24 months (HR, 3.79), with comorbidities potentially explaining later excess mortality.

Conclusions:

  • Young patients with severe sepsis experience elevated long-term mortality risks.
  • The initial 24 months post-discharge represent the period of highest mortality risk for these patients.
  • Chronic comorbidities may be a significant factor in the excess mortality observed in sepsis survivors.
Abstract

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