Related Experiment Video
Updated: Feb 10, 2026

Robotic-assisted Left Pneumonectomy For Vanishing Lung Syndrome
Published on: January 23, 2026
Obstetric Management of Loeys-Dietz Syndrome
Melissa L Russo1, Neelima Sukhavasi, Veena Mathur
1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Warren Alpert Medical School of Brown University, Women and Infants Hospital of Rhode Island, Providence, Rhode Island; and the Department of Obstetrics and Gynecology, Baylor College of Medicine, and the Departments of Molecular and Human Genetics and Pediatric Cardiology, Baylor College of Medicine, Texas Children's Pavilion for Women, Houston, Texas.
Background:
Loeys-Dietz syndrome is associated with arterial tortuosity and aortic dissection. Pregnancy may be a period of increased risk for aortic dissection.
Case:
A 16-year-old primigravid girl was referred to our center with a family history of aortic dissection. Loeys-Dietz syndrome was suspected, and genetic testing confirmed the TGFβ2 (c.988C>T) mutation. A cesarean delivery was performed at 36 weeks of gestation, with no cardiovascular complications. In this case, the uterine vessels were significantly tortuous; this may be an additional finding in Loeys-Dietz syndrome.
Conclusion:
Women with Loeys-Dietz syndrome warrant special consideration in obstetric management secondary to the risk for aortic dissection. It is recommended that a multidisciplinary team with knowledge about connective tissue disorders and expertise in aortic surgery coordinate maternal obstetric and cardiovascular care.
Related Concept Videos
Acute Coronary Syndrome V: Nursing Management
Nephrotic Syndrome II : Assessment and Medical Management
Nephrotic Syndrome III : Nursing Management
Irritable Bowel Syndrome III: Medical and Nursing Management
Nephrotic Syndrome I : Introduction
Acute Coronary Syndrome I: Introduction

