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Related Concept Videos

Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
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Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

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Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

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RNA Splicing01:32

RNA Splicing

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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
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Related Experiment Video

Updated: Feb 10, 2026

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis
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Non-coding RNA in cystic fibrosis.

Arlene M A Glasgow1, Chiara De Santi1, Catherine M Greene2

  • 1Lung Biology Group, Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

Biochemical Society Transactions
|May 11, 2018
PubMed
Summary

Altered non-coding RNAs (ncRNAs), including microRNAs and long non-coding RNAs, are linked to cystic fibrosis (CF) pathogenesis. This review explores ncRNA roles in CF and their potential for future clinical applications.

Keywords:
cystic fibrosislong non-coding RNAmicroRNAnon-coding RNA

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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Non-coding RNAs (ncRNAs) are crucial regulatory molecules with diverse functions.
  • Altered ncRNA expression is implicated in various human diseases, including cystic fibrosis (CF).
  • Cystic fibrosis is caused by defects in the cystic fibrosis transmembrane receptor (CFTR) chloride channel.

Purpose of the Study:

  • To review current knowledge on ncRNA expression and function in CF.
  • To discuss the potential clinical applications of ncRNAs in managing CF.

Main Methods:

  • Literature review of studies on ncRNA expression and function in CF.
  • Analysis of existing research focusing on microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in CF.

Main Results:

  • Quantitative changes in certain ncRNAs are associated with CF.
  • Most research has focused on miRNAs, with limited studies on lncRNAs in CF.
  • ncRNAs represent potential biomarkers and therapeutic targets for CF.

Conclusions:

  • ncRNAs play a significant role in CF pathophysiology.
  • Further research into lncRNAs in CF is warranted.
  • ncRNA-based diagnostics and therapeutics hold promise for CF management.