Related Experiment Video
Updated: Feb 10, 2026

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
Published on: November 10, 2023
[Hypoplastic acute promyelocytic leukemia with continuous hypocellular bone marrow after remission]
Toshiki Nakamura1, Junya Makiyama1,2, Ayumi Matsuura3
1Department of Hematology, National Hospital Organization Nagasaki Medical Center.
This study reports a rare case of hypoplastic acute promyelocytic leukemia in an elderly patient. Prompt treatment with ATRA and ATO achieved complete remission, highlighting the importance of accurate diagnosis.
Area of Science:
- Hematology
- Oncology
Background:
- Hypoplastic acute myeloid leukemia (AML) presents with low bone marrow cellularity, posing diagnostic challenges.
- Distinguishing hypoplastic AML from aplastic anemia and myelodysplastic syndromes is crucial for appropriate management.
Observation:
- An 87-year-old female presented with pancytopenia, coagulopathy, and a hypocellular bone marrow.
- Histopathology and genetic analysis revealed acute promyelocytic leukemia (APL) cells with the PML-RARA fusion gene.
Findings:
- The patient was diagnosed with hypoplastic acute promyelocytic leukemia.
- Treatment with all-trans retinoic acid (ATRA) led to complete remission (CR) in 29 days.
- Consolidation therapy with arsenic trioxide (ATO) maintained CR, though hypocellular bone marrow persisted.
Implications:
- Accurate diagnosis of hypoplastic AML requires both cytogenetic and morphological evaluation.
- This case underscores the efficacy of ATRA and ATO in treating hypoplastic APL.
- Hypocellularity may persist even after achieving remission in some APL cases.
More Related Videos
08:31Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
09:57Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
Published on: March 5, 2018
Related Concept Videos
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
Continuing Care
Continuity of a Function
Continuity Equation
The mass flow rate is expressed as:
Continuity Equation
Equation of Continuity