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Related Concept Videos

Peptide Bonds02:43

Peptide Bonds

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A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
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Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

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Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
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Preparation of Epoxides03:00

Preparation of Epoxides

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Overview
Epoxides result from alkene oxidation, which can be achieved by a) air, b) peroxy acids, c) hypochlorous acids, and d) halohydrin cyclization.
Epoxidation with Peroxy Acids
Epoxidation of alkenes via oxidation with peroxy acids involves the conversion of a carbon–carbon double bond to an epoxide using the oxidizing agent meta-chloroperoxybenzoic acid, commonly known as MCPBA. Since the O–O bond of peroxy acids is very weak, the addition of electrophilic oxygen of peroxy acids to...
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Preparation of Amides01:29

Preparation of Amides

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Amides are synthesized by treating carboxylic acids with amines in the presence of dehydrating agents like dicyclohexylcarbodiimide (DCC).
The DCC-promoted synthesis of amides begins with the protonation of DCC by carboxylic acid. The protonation makes it a better acceptor. Next, the addition of carboxylate to the protonated carbodiimide gives a reactive acylating agent.
Subsequently, the amine acts as a nucleophile that attacks the acylating agent to form a tetrahedral intermediate. In the...
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Preparation of Nitriles01:12

Preparation of Nitriles

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One of the common methods to prepare nitriles is the dehydration of amides. This method requires strong dehydrating agents like phosphorous pentoxide or boiling acetic anhydride for converting amides to nitriles. Another reagent namely, thionyl chloride also accomplishes the dehydration of amides, where amide acts as a nucleophile. The first step of the mechanism involves the nucleophilic attack by the amide on the thionyl chloride to form an intermediate. In the next step, the electron pairs...
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Weak Base Solutions03:21

Weak Base Solutions

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Some compounds produce hydroxide ions when dissolved by chemically reacting with water molecules. In all cases, these compounds react only partially and so are classified as weak bases. These types of compounds are also abundant in nature and important commodities in various technologies. For example, global production of the weak base ammonia is typically well over 100 metric tons annually, being widely used as an agricultural fertilizer, a raw material for chemical synthesis of other...
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Related Experiment Video

Updated: Feb 10, 2026

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
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A General Method to Prepare Peptide-Based Supramolecular Hydrogels.

Dan Yuan1, Junfeng Shi1, Ning Zhou1

  • 1Brandeis University, Waltham, MA, USA.

Methods in Molecular Biology (Clifton, N.J.)
|May 11, 2018
PubMed
Summary
This summary is machine-generated.

Researchers developed a general method to create peptide-based supramolecular hydrogels. This versatile soft material is formed through noncovalent interactions, enabling diverse applications.

Keywords:
EnzymeHydrogelationPeptidepH

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Area of Science:

  • Materials Science
  • Biochemistry
  • Polymer Science

Background:

  • Supramolecular hydrogels are versatile soft materials with increasing research attention.
  • Peptide-based hydrogels are synthesized via noncovalent intermolecular interactions.
  • Hydrogelation typically involves balancing water hydration and hydrophobic interactions from a homogeneous solution.

Purpose of the Study:

  • To present a general method for preparing supramolecular hydrogels using small peptides.
  • To demonstrate the hydrogel preparation process with two specific examples.

Main Methods:

  • Utilizing noncovalent intermolecular interactions to initiate hydrogelation.
  • Starting from a homogeneous peptide solution.
  • Achieving a balance between water hydration and hydrophobic interactions.

Main Results:

  • Successful preparation of supramolecular hydrogels from small peptides.
  • Demonstration of the general method through two distinct examples.
  • Formation of hydrogels via controlled self-assembly processes.

Conclusions:

  • A general and versatile method for creating peptide-based supramolecular hydrogels has been established.
  • This method offers a pathway for developing novel soft materials with potential applications.
  • The described approach facilitates the synthesis of functional hydrogels through controlled self-assembly.