Related Experiment Video
Updated: Feb 10, 2026
11:58
The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions
Published on: October 18, 2017
9.9K
Chemical Proteomics of Host-Microbe Interactions
1Astbury Centre for Structural Molecular Biology, School of Chemistry, University of Leeds, Leeds, LS2 9JT, United Kingdom.
Proteomics
|May 11, 2018
Summary
Chemical proteomic tools reveal molecular players in host-microbe interactions. This review highlights advances in using small molecules to study protein function and modifications at the host-microbe interface.
Area of Science:
- Microbiology
- Proteomics
- Chemical Biology
Background:
- The host-microbe interface involves complex biological interactions.
- Microbial pathogens and symbionts dynamically alter host and microbial protein expression and function.
- Identifying molecular players in these dynamic, multispecies systems is challenging.
Purpose of the Study:
- To review recent advances in chemical proteomic approaches.
- To highlight the application of chemical tools at the host-microbe interface.
Main Methods:
- Chemical proteomic approaches utilize small molecule chemical tools.
- These tools interrogate protein function, interactions, and posttranslational modifications.
Main Results:
- Chemical proteomics offers powerful methods to dissect host-microbe interactions.
- Advances enable detailed study of protein dynamics in complex biological systems.
Conclusions:
- Chemical proteomic strategies are crucial for understanding host-microbe molecular mechanisms.
- These methods provide insights into pathogen-host and symbiont-host relationships.
Keywords:
activity-based protein profilingchemical probechemical proteomicsmetabolic taggingphotoaffinity labelingMore Related Videos
Related Concept Videos
01:33Proteomics
9.8K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
9.8K
02:37Types of Chemical Bonds
94.5K
Chemical bonding theories were pioneered by American chemist Gilbert N. Lewis. He developed a model called the Lewis model to explain the type and formation of different bonds. Chemical bonding is central to chemistry; it explains how atoms or ions bond together to form molecules. It explains why some bonds are strong and others are weak, or why one carbon bonds with two oxygens and not three; why water is H2O and not H4O.
94.5K
02:52Chemical Formulas
61.5K
A chemical formula presents information about the proportions of atoms constituting a particular chemical compound or molecule, mainly using symbols of elements and numbers. At times other symbols, such as dashes, parentheses, brackets, commas, plus, and minus signs, are also used. A chemical formula can be one of three types – molecular, empirical, and structural.
61.5K
03:10Chemical Equations
82.0K
Chemical equations represent the identities and relative quantities of substances involved in a chemical reaction. The substances undergoing reaction are called reactants, and their formulas are placed on the left side of the equation. The substances generated by the reaction are called products, and their formulas are placed on the right side of the equation. Plus signs (+) separate individual reactant and product formulas, and an arrow (→) separates the reactant and product (left and right)...
82.0K
01:19Chemical Reactions
96.0K
A chemical reaction is a process by which the bonds in the atoms of substances are rearranged to generate new substances. Matter cannot be created or destroyed in a chemical reaction—the same type and number of atoms that make up the reactants are still present in the products. Merely, the rearrangement of chemical bonds produces new compounds.
Chemical Reactions Rearrange Atoms into New Substances
A chemical reaction takes starting materials—the reactants—and changes them...
Chemical Reactions Rearrange Atoms into New Substances
A chemical reaction takes starting materials—the reactants—and changes them...
96.0K
02:39Predator-Prey Interactions
21.7K
Predators consume prey for energy. Predators that acquire prey and prey that avoid predation both increase their chances of survival and reproduction (i.e., fitness). Routine predator-prey interactions elicit mutual adaptations that improve predator offenses, such as claws, teeth, and speed, as well as prey defenses, including crypsis, aposematism, and mimicry. Thus, predator-prey interactions resemble an evolutionary arms race.
21.7K