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Updated: Feb 10, 2026

Rapid Optical Clearing for Semi-High-Throughput Analysis of Tumor Spheroids
Published on: August 23, 2022
On the Runtime Analysis of the Clearing Diversity-Preserving Mechanism
Edgar Covantes Osuna1, Dirk Sudholt2
1Department of Computer Science, University of Sheffield, Sheffield, S1 4DP, United Kingdom ecovantes1@sheffield.ac.uk.
Abstract:
Clearing is a niching method inspired by the principle of assigning the available resources among a niche to a single individual. The clearing procedure supplies these resources only to the best individual of each niche: the winner. So far, its analysis has been focused on experimental approaches that have shown that clearing is a powerful diversity-preserving mechanism. Using rigorous runtime analysis to explain how and why it is a powerful method, we prove that a mutation-based evolutionary algorithm with a large enough population size, and a phenotypic distance function always succeeds in optimising all functions of unitation for small niches in polynomial time, while a genotypic distance function requires exponential time. Finally, we prove that with phenotypic and genotypic distances, clearing is able to find both optima for and several general classes of bimodal functions in polynomial expected time. We use empirical analysis to highlight some of the characteristics that makes it a useful mechanism and to support the theoretical results.
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