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Prolonged QRS Widening After Aripiprazole Overdose.

Maryann Mazer-Amirshahi1,2, Robert Porter3, Kayla Dewey1,2

  • 1From the Department of Emergency Medicine, MedStar Washington Hospital Center.

Pediatric Emergency Care
|May 11, 2018
PubMed
Summary

Aripiprazole overdose in a CYP2D6 poor metabolizer adolescent caused prolonged QRS widening without cardiac compromise. Toxicity duration was extended in this patient with genetic variation affecting drug metabolism.

Area of Science:

  • Pharmacology
  • Cardiology
  • Genetics

Background:

  • Aripiprazole is an atypical antipsychotic known for its long half-life.
  • Overdose can lead to prolonged somnolence and cardiac issues, including QT interval prolongation.

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