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Updated: Feb 10, 2026

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A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
Published on: October 6, 2019
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Prolonged QRS Widening After Aripiprazole Overdose
Maryann Mazer-Amirshahi1,2, Robert Porter3, Kayla Dewey1,2
1From the Department of Emergency Medicine, MedStar Washington Hospital Center.
Pediatric Emergency Care
|May 11, 2018
Summary
Aripiprazole overdose in a CYP2D6 poor metabolizer adolescent caused prolonged QRS widening without cardiac compromise. Toxicity duration was extended in this patient with genetic variation affecting drug metabolism.
Area of Science:
- Pharmacology
- Cardiology
- Genetics
Background:
- Aripiprazole is an atypical antipsychotic known for its long half-life.
- Overdose can lead to prolonged somnolence and cardiac issues, including QT interval prolongation.
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