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Related Concept Videos

Adhesion01:14

Adhesion

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Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow...
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Cell Adhesion in Plants01:14

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Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
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Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
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Cell Adhesion Molecules - Types and Functions01:20

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Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
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Light as Energy01:35

Light as Energy

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The energy required to carry out photosynthesis is light— typically electromagnetic radiation from the sun. The range of all possible wavelengths is known as the electromagnetic spectrum.
Photons
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The Cell Cycle Control System01:28

The Cell Cycle Control System

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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
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Related Experiment Video

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Determination of the Photoisomerization Quantum Yield of a Hydrazone Photoswitch
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Visible light controls cell adhesion on a photoswitchable biointerface.

Zunzhen Ming1, Xin Hua1, Yuan Xue1

  • 1Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130# Meilong Road, Shanghai, 200237, PR China.

Colloids and Surfaces. B, Biointerfaces
|May 11, 2018
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel bioactive surface using a light-sensitive molecule. This surface controls cell adhesion and detachment with visible light, offering potential for biosensors and tissue engineering.

Keywords:
Cell adhesionPhotoswitchSelf-assembled monolayerSurface regenerationVisible light response

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Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Cell Biology

Background:

  • Bioactive surfaces are crucial for applications like biosensors and tissue engineering.
  • Developing surfaces with controllable cell interactions is a key research area.
  • Existing methods may lack precise control or biocompatibility.

Purpose of the Study:

  • To fabricate a novel bioactive surface using a dopamine-containing photoswitch molecule.
  • To investigate the photoswitchable properties and cell interaction behavior of the self-assembled monolayer (SAM).
  • To explore the potential of this surface for biomedical applications through light-induced cell adhesion and detachment control.

Main Methods:

  • Fabrication of a dopamine-contained photoswitch molecule (compound 1).
  • Formation of a self-assembled monolayer (SAM) on substrates.
  • Contact angle analysis to determine surface hydrophobicity/hydrophilicity.
  • Cell adhesion and detachment experiments under visible light irradiation (λex = 530 nm).

Main Results:

  • The fabricated SAM exhibited good photoswitch ability and excellent fatigue resistance.
  • The surface was hydrophobic before irradiation, promoting cell adhesion.
  • After light irradiation, the surface became hydrophilic, inducing cell detachment (unfouling).
  • Reversible regulation of cell adhesion and detachment was achieved using visible light.

Conclusions:

  • The developed photoswitchable SAM provides a biologically friendly surface coating.
  • Visible light stimulation allows for reversible control over cell adhesion and detachment.
  • This technology opens new possibilities for bioactive surfaces in biomedical applications, including tissue engineering and biosensors.