Visible light controls cell adhesion on a photoswitchable biointerface
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Updated: Feb 10, 2026

Determination of the Photoisomerization Quantum Yield of a Hydrazone Photoswitch
Published on: February 7, 2022
Zunzhen Ming1, Xin Hua1, Yuan Xue1
1Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130# Meilong Road, Shanghai, 200237, PR China.
Abstract:
Bioactive surfaces with specific interactions with cells have been greatly interested due to their potential applications in biosensors and tissue engineering. Herein, we fabricated a dopamine contained photoswitch molecule (compound 1) which could form self-assembled monolayer (SAM) on substrates. The SAM showed a good photoswitch ability and manifested excellent fatigue resistance, which displayed its potential application as a biologically friendly surface coating. Contact angle analysis and cell experiments exhibited that the SAM surface was hydrophobic before irradiation which favored cell adhesion, while, it turned hydrophilic and induced cell unfouling or detachment after light irradiation. The uses of visible light stimulation (λex = 530 nm) and the reversible regulation on cell adhesion and detachment should open up new avenues for bioacitve surfaces in biomedical applications.
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