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Sustained Release Drug Delivery Applications of Polyurethanes
Michael B Lowinger1,2, Stephanie E Barrett3, Feng Zhang4
1College of Pharmacy, The University of Texas at Austin, 2409 University Avenue, Austin, TX 78712, USA. michael.lowinger@utexas.edu.
Pharmaceutics
|May 12, 2018
Summary
Polyurethanes offer versatile applications in modified drug delivery systems. This review highlights their use in sustained release formulations, examining factors influencing drug release kinetics.
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Biomedical Engineering
Background:
- Polyurethanes have broad industrial applications.
- Drug delivery research using polyurethanes has seen recent resurgence.
- Understanding polyurethane chemistry is key for drug delivery.
Purpose of the Study:
- To review polyurethane applications in modified-release drug delivery.
- To discuss factors affecting drug release from polyurethane systems.
- To highlight recent advancements and assessment methods.
Main Methods:
- Literature review of polyurethane-based drug delivery systems.
- Analysis of polyurethane chemistry and drug release mechanisms.
- Examination of factors influencing drug release kinetics.
Main Results:
- Polyurethanes are effective in developing modified-release drug delivery systems.
- Hydrophilic swelling and pore formers significantly modulate drug release.
- Drug properties and mechanical characteristics impact formulation performance.
Conclusions:
- Polyurethanes are a promising material for advanced drug delivery.
- Further research into material properties and formulation design is warranted.
- Optimizing polyurethane-based systems can enhance therapeutic outcomes.
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