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Endocan Levels and Endothelial Dysfunction in Patients With Sarcoidosis

Gonul Aciksari1, Murat Kavas2, Adem Atici3

  • 11 Department of Cardiology, Istanbul Medeniyet University Goztepe Training and Research Hospital, Istanbul, Turkey.

Angiology
|May 12, 2018
PubMed

Insights

Sarcoidosis patients show higher endocan levels and impaired endothelial function (lower FMD), indicating potential early atherosclerosis. This suggests endocan as a marker for vascular pathology in sarcoidosis.

Area of Science:

  • Cardiovascular Research
  • Inflammatory Diseases
  • Vascular Biology

Background:

  • Systemic inflammation is common in sarcoidosis and atherosclerosis.
  • Endothelial-cell specific molecule 1 (endocan) is a marker of vascular pathology, inflammation, and endothelial dysfunction.
  • Sarcoidosis patients often lack conventional cardiovascular risk factors, necessitating investigation into other vascular involvement markers.

Purpose of the Study:

  • To evaluate vascular involvement in sarcoidosis by measuring serum endocan levels and brachial artery flow-mediated dilation (FMD).
  • To assess endothelial dysfunction in sarcoidosis patients without traditional cardiovascular risk factors.

Main Methods:

  • Enzyme-linked immunoassay was used to measure serum endocan concentrations.
  • Brachial artery flow-mediated dilation (FMD) was assessed to evaluate endothelial function.
  • Study included 53 sarcoidosis patients and 40 healthy controls.

Main Results:

  • Sarcoidosis patients exhibited significantly higher serum endocan levels compared to healthy controls (306 [68] ng/mL vs 269 [73] ng/mL; P = .039).
  • Patients with sarcoidosis demonstrated significantly lower FMD values, indicative of endothelial dysfunction (2.7% [2.3%-3.2%] vs 8% [5%-13%]; P < .001).
  • A significant negative correlation was observed between serum endocan levels and FMD in the sarcoidosis group (r = -0.325, P < .007).

Conclusions:

  • Sarcoidosis is associated with elevated serum endocan levels and impaired endothelial function.
  • These findings suggest that sarcoidosis may involve endothelial dysfunction and early-stage atherosclerosis.
  • Endocan may serve as a valuable biomarker for assessing vascular pathology in sarcoidosis.

Keywords:
atherosclerosisendocanendothelial dysfunctionsarcoidosis

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