Relationships Between Perinatal Interventions, Maternal-Infant Microbiomes, and Neonatal Outcomes
Gregory Valentine1, Derrick M Chu2, Christopher J Stewart3
1Department of Pediatrics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA; Division of Neonatology, Texas Children's Hospital, West Tower, Suite B.06177, Mail Stop: BCM320, Houston, TX 77030, USA.
Clinics in Perinatology
|May 12, 2018
Summary
The human microbiome develops rapidly in early life. Understanding prenatal and postnatal influences on infant gut microbes is crucial for future health.
Area of Science:
- Microbiology
- Developmental Biology
- Immunology
Background:
- The human microbiome's development and diversity are established early in life.
- Key factors influencing the prenatal and postnatal microbiome remain largely uncharacterized.
- Early-life microbiome composition is linked to later metabolic health outcomes.
Purpose of the Study:
- To review current literature on the development of the fetal and neonatal microbiome.
- To identify key determinants and sources shaping the early-life microbiome.
- To outline future research directions for understanding microbiome development.
Main Methods:
- Literature review of existing studies on early-life microbiome development.
- Analysis of factors influencing microbial colonization in utero and postnatally.
- Synthesis of current knowledge on microbiome-shaping mechanisms.
Main Results:
- The microbiome's establishment is a dynamic process influenced by multiple factors.
- Prenatal and early postnatal environments significantly shape microbial communities.
- Specific maternal and environmental factors are critical determinants.
Conclusions:
- Further research is needed to fully elucidate the prenatal microbiome.
- Understanding early-life microbial development is essential for promoting long-term health.
- Targeted interventions may leverage microbiome modulation for health benefits.
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