Relationships Between Perinatal Interventions, Maternal-Infant Microbiomes, and Neonatal Outcomes

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Gregory Valentine1, Derrick M Chu2, Christopher J Stewart3

  • 1Department of Pediatrics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA; Division of Neonatology, Texas Children's Hospital, West Tower, Suite B.06177, Mail Stop: BCM320, Houston, TX 77030, USA.

Clinics in Perinatology
|May 12, 2018
PubMed

Insights

The human microbiome develops rapidly in early life. Understanding prenatal and postnatal influences on infant gut microbes is crucial for future health.

Area of Science:

  • Microbiology
  • Developmental Biology
  • Immunology

Background:

  • The human microbiome's development and diversity are established early in life.
  • Key factors influencing the prenatal and postnatal microbiome remain largely uncharacterized.
  • Early-life microbiome composition is linked to later metabolic health outcomes.

Purpose of the Study:

  • To review current literature on the development of the fetal and neonatal microbiome.
  • To identify key determinants and sources shaping the early-life microbiome.
  • To outline future research directions for understanding microbiome development.

Main Methods:

  • Literature review of existing studies on early-life microbiome development.
  • Analysis of factors influencing microbial colonization in utero and postnatally.
  • Synthesis of current knowledge on microbiome-shaping mechanisms.

Main Results:

  • The microbiome's establishment is a dynamic process influenced by multiple factors.
  • Prenatal and early postnatal environments significantly shape microbial communities.
  • Specific maternal and environmental factors are critical determinants.

Conclusions:

  • Further research is needed to fully elucidate the prenatal microbiome.
  • Understanding early-life microbial development is essential for promoting long-term health.
  • Targeted interventions may leverage microbiome modulation for health benefits.

Keywords:
MicrobiomeNeonatePerinatalPregnancyPrematurityPreterm birth

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