Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Rosacea].

E Grosshans1

  • 1Clinique dermatologique de la Faculté de Médecine, Strasbourg.

Presse Medicale (Paris, France : 1983)
|December 17, 1988
PubMed
Summary
This summary is machine-generated.

Rosacea is a facial vascular disease, not a skin condition, involving microcirculatory dysfunction. Current treatments manage symptoms but not the underlying vascular issue, prompting research into new therapies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[150 years of Annales de dermatologie 1868-2018].

Annales de dermatologie et de venereologie·2019
Same author

[Reactive perforating collagenosis].

Annales de dermatologie et de venereologie·2012
Same author

[Chronically neglected malignant skin tumours].

Annales de dermatologie et de venereologie·2012
Same author

[Annular elastolytic giant cell granuloma].

Annales de dermatologie et de venereologie·2010
Same author

Trichoblastic carcinoma of the pinna. A rare case.

Hippokratia·2009
Same author

[Artefacts in dermatopathology].

Annales de dermatologie et de venereologie·2009

Area of Science:

  • Dermatology
  • Vascular Biology

Background:

  • Rosacea is reclassified from a follicular disease to a vascular disorder of the face.
  • It presents with complications like telangiectasias, papules, pustules, granulomas, edema, and seboglandular hyperplasia.

Purpose of the Study:

  • To re-evaluate the pathophysiology of rosacea.
  • To identify the primary vascular abnormality and its role in facial complications.
  • To guide future therapeutic strategies targeting the root cause.

Main Methods:

  • Clinical observation and analysis of rosacea manifestations.
  • Pathophysiological investigation focusing on facial microcirculation.
  • Review of current therapeutic interventions and their limitations.

Related Experiment Videos

Main Results:

  • Rosacea's core issue is a microcirculatory disturbance in facial angular veins, impacting brain-cooling mechanisms.
  • Flushing is identified as the primary clinical sign of this vascular dysfunction.
  • Existing therapies (tetracycline, metronidazole, isotretinoin) treat complications but not the fundamental vascular problem.

Conclusions:

  • Rosacea is fundamentally a vascular disease of the face.
  • Therapeutic research should focus on addressing the underlying microcirculatory dysfunction.
  • Novel treatments targeting alpha-sympathomimetic activity and opioid mediators are promising.