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Potential Clinical Benefits of D-ribose in Ischemic Cardiovascular Disease

Linda M Shecterle1, Kathleen R Terry1, John A St Cyr1

  • 1Research and Development, Jacqmar, Inc.

Cureus
|May 12, 2018
PubMed

Insights

Cardiovascular disease, including atherosclerosis, impairs heart energy production. D-ribose may help restore adenosine triphosphate (ATP) levels, improving heart function after ischemia.

Area of Science:

  • Cardiology
  • Biochemistry
  • Metabolic Research

Background:

  • Cardiovascular disease is a leading global cause of death.
  • Atherosclerosis progression is influenced by genetics and lifestyle.
  • Myocardial ischemia, common in atherosclerosis, reduces cellular adenosine triphosphate (ATP) levels, impairing heart function.

Purpose of the Study:

  • To review ischemic cardiovascular disease.
  • To explore the potential role of D-ribose in improving myocardial energy metabolism.
  • To assess D-ribose's benefits for heart function following ischemia.

Main Methods:

  • Literature review of ischemic cardiovascular disease.
  • Analysis of studies on D-ribose and cellular energy levels.
  • Evaluation of pre-clinical and clinical data on D-ribose efficacy.

Main Results:

  • D-ribose is a naturally occurring carbohydrate.
  • Pre-clinical studies suggest D-ribose increases cellular ATP levels.
  • Clinical evaluations indicate potential benefits of D-ribose in ischemia.

Conclusions:

  • D-ribose shows promise in restoring myocardial ATP levels.
  • D-ribose may improve cardiac function in ischemic conditions.
  • Further research into D-ribose for cardiovascular health is warranted.

Keywords:
adenine nucleotidesadenosine triphosphatecardiologycardiovascular diseasecardiovascular surgeryclinical benefitsd-ribosepre-clinical and clinical trials

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