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Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT
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FDG-PET CT in the evaluation of primary and secondary pancreatic malignancies

Casey E Bohl1, Sara M Federico2, Giles W Robinson2

  • 1Department of Radiology, Methodist University Hospital, Memphis, Tennessee.

Pediatric Blood & Cancer
|May 12, 2018
PubMed

Insights

Pancreatic cancers and metastases are rare in children but metabolically active. 18F-fluorodeoxyglucose-positron emission tomography computed tomography (FDG-PET CT) can characterize these rare pediatric pancreatic tumors.

Area of Science:

  • Oncology
  • Pediatric Oncology
  • Medical Imaging

Background:

  • Primary pancreatic malignancies and metastases are rare in pediatric patients.
  • Pancreatoblastoma and solid-pseudopapillary tumors are common in children and teenagers, respectively.
  • Secondary pancreatic malignancies, often non-Hodgkin lymphomas and sarcomas, are more frequent than primary tumors in children.

Observation:

  • A retrospective analysis reviewed 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) CT scans of pediatric patients with pancreatic malignancies.
  • Three cases of primary pancreatic cancer (pancreatoblastoma, solid-pseudopapillary tumor, adenocarcinoma) and 12 cases of metastatic disease (non-Hodgkin lymphomas, sarcomas, malignant rhabdoid tumor) were identified.
  • All identified tumors demonstrated elevated FDG uptake, indicating metabolic activity.

Findings:

  • Both primary pancreatic tumors and pancreatic metastases in pediatric patients exhibit increased metabolic activity.
  • FDG-PET CT is a valuable tool for the functional characterization of these rare pediatric pancreatic malignancies.
  • Metabolic activity, as measured by FDG uptake, was elevated but variable across different tumor types.

Implications:

  • FDG-PET CT can aid in the diagnosis and characterization of rare pancreatic tumors in children.
  • Understanding the metabolic profile of pediatric pancreatic malignancies may inform treatment strategies.
  • This study highlights the utility of advanced imaging techniques in evaluating rare pediatric cancers.
Abstract

Keywords:
CTFDGPEToncologypancreaspediatric

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