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Related Experiment Video

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Measuring and Modeling Contractile Drying in Human Stratum Corneum
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Stratum corneum substantivity: drug development implications.

Becky S Li1,2, John Havens Cary3, Howard I Maibach4

  • 1Howard University College of Medicine, 520 W Street NW, Washington, DC, 20059, USA. Becky.Li@ucsf.edu.

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|May 13, 2018
PubMed
Summary
This summary is machine-generated.

Skin substantivity, the prolonged retention of chemicals on and in skin, is crucial for topical drug delivery and consumer products. Understanding its mechanisms can optimize dosing strategies and inform dermatotoxicology research.

Keywords:
Percutaneous penetrationStratum corneum adherenceStratum corneum bindingSubstantivity

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Area of Science:

  • Dermatology
  • Pharmacology
  • Materials Science

Background:

  • Skin penetration is influenced by numerous factors, with substantivity being a key determinant of chemical retention.
  • Understanding substantivity is vital for optimizing topical dosing strategies in treating skin conditions affecting the stratum corneum.
  • Substantivity impacts various consumer products, including sunscreens, cosmetics, and insect repellents, requiring prolonged skin adherence.

Purpose of the Study:

  • To explore the mechanisms of chemical substantivity on and within the skin.
  • To investigate the implications of substantivity for topical dosing strategies in dermatological treatments.
  • To assess the role of substantivity in the efficacy and safety of skin-adherent consumer products.

Main Methods:

  • Literature review on factors influencing skin penetration and substantivity.
  • Analysis of existing research on stratum corneum interactions with topical agents.
  • Exploration of toxicological data related to chemical accumulation due to excessive substantivity.

Main Results:

  • Substantivity allows penetrants to remain on and in skin for extended periods, influencing topical product performance.
  • Stratum corneum adherence, a component of substantivity, can modulate percutaneous absorption, potentially reducing systemic toxicity.
  • Excessive substantivity may lead to the toxic accumulation of chemicals within the skin.

Conclusions:

  • Further research into substantivity mechanisms can enhance topical dosing strategies for skin pathologies.
  • Understanding substantivity is essential for developing effective and safe sunscreens, cosmetics, and insect repellents.
  • Insights into substantivity can advance the fields of dermatotoxicology and dermatopharmacology, improving skin health and safety.