Related Experiment Video

Updated: Jan 26, 2026

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
10:08

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Published on: February 17, 2018

14.0K

Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic

Juliana Pereira Borges1, Fernanda de Souza Nogueira Sardinha Mendes2, Gabriella de Oliveira Lopes3

  • 1Laboratory of Physical Activity and Health Promotion, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

International Journal of Cardiology
|May 14, 2018
PubMed

Insights

Microvascular endothelial function is similarly impaired in patients with Chronic Chagas cardiomyopathy (CCC) and ischemic cardiomyopathy. This study compared skin microvascular blood flow in these patients and healthy controls.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Tropical Medicine

Background:

  • Pathophysiological pathways in Chronic Chagas cardiomyopathy (CCC) and other cardiomyopathies are not fully understood.
  • Systemic microvascular abnormalities are implicated in ischemic heart disease pathogenesis.
  • Microvascular endothelial function in CCC requires further investigation.

Purpose of the Study:

  • To compare microvascular endothelial function in patients with CCC versus those with ischemic cardiomyopathy.
  • To elucidate the role of microvascular abnormalities in CCC pathogenesis.

Main Methods:

  • Assessed microvascular reactivity in 21 CCC patients, 21 ischemic cardiomyopathy patients, and 21 healthy controls.
  • Measured forearm skin microvascular blood flow using laser speckle contrast imaging.
  • Utilized acetylcholine (ACh) iontophoresis to assess endothelial-dependent vasodilation.

Main Results:

  • Healthy controls exhibited significantly greater ACh-induced forearm blood flow increase compared to both patient groups (p < 0.0001).
  • Patients with CCC and ischemic cardiomyopathy showed comparable impairments in ACh-induced skin blood flow changes (p = 0.55).

Conclusions:

  • Endothelial microvascular function is equally impaired in patients with CCC and ischemic cardiomyopathy.
  • Shared microvascular dysfunction may contribute to the pathophysiology of both conditions.
Abstract

Keywords:
Chagas heart diseaseCoronary artery diseaseCutaneous vascular conductanceEndothelial functionIschemic heart diseaseMicrovascular flowmetry

More Related Videos

Assessment of Vascular Function in Patients With Chronic Kidney Disease08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.7K
Non-invasive Assessment of Microvascular and Endothelial Function05:41

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

16.6K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
459
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
384
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
507
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
531
One-Way ANOVA: Equal Sample Sizes01:15

One-Way ANOVA: Equal Sample Sizes

One-Way ANOVA can be performed on three or more samples with equal or unequal sample sizes. When one-way ANOVA is performed on two datasets with samples of equal sizes, it can be easily observed that the computed F statistic is highly sensitive to the sample mean.
Different sample means can result in different values for the variance estimate: variance between samples. This is because the variance between samples is calculated as the product of the sample size and the variance between the...
4.0K
Electric Field of Two Equal and Opposite Charges01:30

Electric Field of Two Equal and Opposite Charges

Atoms generally contain the same number of positively and negatively charged particles, protons, and electrons. Hence, they are electrically neutral. However, the centers of the positive and negative charges do not always coincide. In such a scenario, the electric field of an atom may not be zero.
A separation of the positive and negative charges can lead to a weak, remnant effect of the positive and negative charges. The expectation is that the more the distance between the positive and...
7.0K