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Updated: Feb 10, 2026

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
Published on: June 20, 2014
Magnetic Resonance Imaging technology-bridging the gap between noninvasive human imaging and optical microscopy
Jonathan R Polimeni1, Lawrence L Wald1
1Athinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, USA; Harvard-Massachusetts Institute of Technology, Division of Health Sciences and Technology, Cambridge, MA, USA.
Abstract:
Technological advances in Magnetic Resonance Imaging (MRI) have provided substantial gains in the sensitivity and specificity of functional neuroimaging. Mounting evidence demonstrates that the hemodynamic changes utilized in functional MRI can be far more spatially and thus neuronally specific than previously believed. This has motivated a push toward novel, high-resolution MR imaging strategies that can match this biological resolution limit while recording from the entire human brain. Although sensitivity increases are a necessary component, new MR encoding technologies are required to convert improved sensitivity into higher resolution. These new sampling strategies improve image acquisition efficiency and enable increased image encoding in the time-frame needed to follow hemodynamic changes associated with brain activation.
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